Korelasi Ekspresi Ki67 dan Indeks Mitosis Pasien Kanker Payudara di RSUD AWS
DOI:
https://doi.org/10.33006/jikes.v7i1.653Abstract
Abstrak
Kanker payudara merupakan penyakit keganasan yang disebabkan oleh pertumbuhan sel-sel abnormal di jaringan payudara. Protein Ki67 terdapat di inti sel dan berkaitan dengan proliferasi dan prognosis sel. Mitosis adalah pembelahan sel yang diatur oleh gen dalam sel. Indeks mitosis digunakan untuk menilai persentase sel tumor yang sedang membelah. Sebanyak 50 sampel data hasil pemeriksaan pasien kanker payudara diambil dari populasi 100 pasien RSUD Abdul Wahab Sjahranie tahun 2022 menggunakan teknik purposive sampling. Jenis penelitian observasional analitik dengan pendekatan cross sectional. Analisis data dengan uji chi square. Hasil penelitian ditemukan mayoritas sebanyak 35 pasien (70,0%) pada usia 41–60 tahun menderita kanker payudara. Terdapat 4 pasien (8,0%) memiliki ekspresi Ki67 rendah (low expression), 22 pasien (44,0%) memiliki ekspresi Ki-67 sedang (intermediate expression), dan 24 pasien (48,0%) memiliki ekspresi Ki67 tinggi (high expression). Sehubungan dengan penilaian indeks mitosis, terdapat 9 pasien (18,0%) dengan skor 1,17 pasien (34,0%) dengan skor 2 dan 24 pasien (48,0%) dengan skor 3. Hasil analisis statistik menunjukkan hubungan yang signifikan antara ekspresi Ki67 dan indeks mitosis dengan nilai p value (0,014) < α (0,05). Ki67 dan indeks mitosis berkorelasi dengan prognosis kanker payudara, ketika sel membelah protein Ki67 yang terikat mengekspresikan selnya.
Kata kunci: ekspresi Ki67, indeks mitosis, kanker payudara
Abstract
Breast cancer is a malignant disease characterized by abnormal cell growth in breast tissue. The Ki67 protein, found in the cell nucleus, is associated with cell proliferation and prognosis. Mitosis is the regulated division of cells controlled by genes. The mitotic index is used to assess the percentage of dividing tumor cells. A total of 50 samples of breast cancer patient examination data were taken from a population of 100 patients at Abdul Wahab Sjahranie Hospital in 2022 using purposive sampling techniques. This observational research employed a cross-sectional approach and analyzed the data using the chi-square test. The findings revealed that the majority of 35 patients (70.0%) with breast cancer were aged 41-60 years. Among them, 4 patients (8.0%) exhibited low Ki67 expression, 22 patients (44.0%) had intermediate Ki67 expression, and 24 patients (48.0%) showed high Ki67 expression. Regarding the mitotic index assessment, 9 patients (18.0%) scored 1, 17 patients (34.0%) scored 2 and 24 patients (48.0%) scored 3. The results of statistical analysis showed a significant relationship between Ki67 expression and mitotic index with p value (0.014) < α (0.05). Ki67 and mitotic index correlate with breast cancer prognosis, when a cell cleaves its cell-expressing bound Ki67 protein.
Keywords: expression of Ki67, mitotic index, breast cancer
References
Amini, R., Muhimmah, I., & Fidianingsih, I. (2021). Analisis Fitur untuk Grading Abnormal Sel Mitosis Pada Kasus Kanker Payudara. Automata, Vol 2, No, 3–7. https://journal.uii.ac.id/AUTOMATA/article/view/17384
Darmayani, P. R. (2016). Indeks mitosis dan indeks proliferasi protein Ki-67 lebih tinggi pada karsinoma sel basal tipe agresif dibandingkan tipe non agresif. Majalah Patologi, 27(1), 1–90.
Firman, N., Syahril, Ke., Abdi, D. A., Nulanda, M., & Dewi, A. S. (2022). Gambaran Faktor Risiko Pasien Kanker Payudara Di RS Ibnu Sina Makassar Tahun 2019. Fakumi Medical Journal …, 2(2), 109–115. http://fmj.fk.umi.ac.id/index.php/fmj/article/view/1
Huang, W., Nebiolo, C., Esbona, K., Hu, R., & Lloyd, R. (2020). Ki67 index and mitotic count: Correlation and variables affecting the accuracy of the quantification in endocrine/neuroendocrine tumors. Annals of Diagnostic Pathology, 48, 151586. https://doi.org/10.1016/j.anndiagpath.2020.151586
Jafari, S. H., Saadatpour, Z., Salmaninejad, A., Momeni, F., Mokhtari, M., Nahand, J. S., Rahmati, M., Mirzaei, H., & Kianmehr, M. (2018). Breast cancer diagnosis: Imaging techniques and biochemical markers. Journal of Cellular Physiology, 233(7), 5200–5213. https://doi.org/10.1002/jcp.26379
Komalasari, T., Hernawan, E., & Putra, R. R. (2019). Pengaruh Konsenterasi Kolkhisin Terhadap Indeks Mitosis Bawang Merah (Allium ascalonicum var. Bima Brebes). Bioleuser, 1(3), 86–91. http://repositori.unsil.ac.id/784/
Meylani, I. T. (2017). Hubungan Faktor Risiko Dengan Ekespresi ER, PR, HER2 Pada Pasien Kanker Payudara Di RSUP DR. Wahidin Sudirohusodo.
Napitupulu, N. L. (2015). Hubungan Ekspresi Ki-67 dengan Indeks Mitosis pada Pasien Kanker Payudara di RSUP H. Adam Malik Tahun 2015. https://repositori.usu.ac.id/handle/123456789/19793
Nielsen, T. O., Leung, S. C. Y., Rimm, D. L., Dodson, A., Acs, B., Badve, S., Denkert, C., Ellis, M. J., Fineberg, S., Flowers, M., Kreipe, H. H., Laenkholm, A. V., Pan, H., Penault-Llorca, F. M., Polley, M. Y., Salgado, R., Smith, I. E., Sugie, T., Bartlett, J. M. S., McShane, L. M., Dowsett, M., & Hayes, D. F. (2021). Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group. Journal of the National Cancer Institute, 113(7), 808–819. https://doi.org/10.1093/jnci/djaa201
Nuratifah, A. P., Irawiraman, H., & ... (2022). Derajat Histopatologi Berhubungan Dengan Ekespresi Ki-67 Pada Kanker Payudara Invasif No Special Type Di RSUD Abdul Wahab….Verdure:HealthScience…,4(1),5055. http://jurnal.stikesmm.ac.id/index.php/verdure/article/view/170%0Ahttp://jurnal.stikesmm.ac.id/index.php/verdure/article/download/170/147
STÅLHAMMAR, G., & HARTMAN, J. (2016). Digital image analysis of Ki67 in hot spots is superior to both manual Ki67 and mitotic counts in breast cancer. International Journal of Laboratory Hematology, 38(1), 42–49. https://doi.org/10.1111/ijlh.12426
Suparman, E., & Suparman, E. (2014). Peran Estrogen Dan Progesteron Terhadap Kanker Payudara. Jurnal Biomedik (Jbm), 6(3), 141–148. https://doi.org/10.35790/jbm.6.3.2014.6319
Wu, Q., Ma, G., Deng, Y., Luo, W., Zhao, Y., Li, W., & Zhou, Q. (2019). Prognostic value of ki-67 in patients with resected triple-negative breast cancer: A meta-analysis. Frontiers in Oncology, 9(OCT), 1–9. https://doi.org/10.3389/fonc.2019.01068
Zhu, C., Song, F., Wang, Y., Dong, H., Guo, Y., & Liu, J. (2019). Breast cancer histopathology image classification through assembling multiple compact CNNs. BMC Medical Informatics and Decision Making, 19(1), 1–17. https://doi.org/10.1186/s12911-019-0913-x
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